Drug Information

Drug General Information
Drug ID
D0M2CT
Former ID
DIB020283
Drug Name
LY456236
Synonyms
LY-456236; LY 456236
Drug Type
Small molecular drug
Indication Discovery agent Investigative [540303]
Formula
C16H15N3O2
InChI
InChI=1S/C16H15N3O2/c1-20-12-5-3-11(4-6-12)19-16-14-9-13(21-2)7-8-15(14)17-10-18-16/h3-10H,1-2H3,(H,17,18,19)
InChIKey
XPJOMFBGKIABQW-UHFFFAOYSA-N
PubChem Compound ID
9926999
PubChem Substance ID
14997422, 24696188, 26755028, 79199119, 85226815, 85789090, 103562070, 104088252, 106913442, 178100376, 229364313, 244981144
Target and Pathway
Target(s) Metabotropicglutamate receptor 1 Target Info Modulator (allosteric modulator) [543745]
KEGG Pathway Calcium signaling pathway
FoxO signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Long-term potentiation
Retrograde endocannabinoid signaling
Glutamatergic synapse
Long-term depression
Estrogen signaling pathway
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Metabotropic glutamate receptor group III pathway
Metabotropic glutamate receptor group I pathway
Endogenous cannabinoid signaling
Reactome G alpha (q) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)
WikiPathways Hypothetical Network for Drug Addiction
GPCRs, Class C Metabotropic glutamate, pheromone
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 540303(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3346).
Ref 543745(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 289).

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