Drug Information

Drug General Information
Drug ID
D0M0KB
Former ID
DIB016445
Drug Name
MK-6592
Synonyms
VX-667
Indication Cancer [ICD9: 140-229; ICD10:C00-C96] Discontinued in Phase 1 [548341]
Company
Vertex Pharmaceuticals Inc
Target and Pathway
Target(s) Aurora protein kinase Target Info Inhibitor [530317]
KEGG Pathway Oocyte meiosis
Reactome APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
RHO GTPases Activate Formins
WikiPathways EGF/EGFR Signaling Pathway
JAK/STAT
Gastric Cancer Network 1
Integrated Breast Cancer Pathway
APC/C-mediated degradation of cell cycle proteins
References
Ref 548341Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800024789)
Ref 530317Clinical experience with aurora kinase inhibitors: a review. Oncologist. 2009 Aug;14(8):780-93.

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