Drug Information

Drug General Information
Drug ID
D0LJ1B
Former ID
DCL000955
Drug Name
Reparixin
Synonyms
Repertaxin; Reparixin [INN]; Reparixin (INN/USAN); (R)-2-(4-isobutylphenyl)propionylmethanesulfonamide; 2-(4-isobutylphenyl)propionylmethanesulfonamide
Drug Type
Small molecular drug
Indication Ischemia-reperfusion injury; Lung transplantation; Graft rejection in heart transplantation [ICD9: 996, 996.84; ICD10:T86, T86.81] Phase 2 [537129], [543171]
Company
Dompe s.p.a.
Formula
C14H21NO3S
InChI
InChI=1S/C14H21NO3S/c1-10(2)9-12-5-7-13(8-6-12)11(3)14(16)15-19(4,17)18/h5-8,10-11H,9H2,1-4H3,(H,15,16)/t11-/m1/s1
InChIKey
KQDRVXQXKZXMHP-LLVKDONJSA-N
CAS Number
CAS 266359-93-7
PubChem Compound ID
9838712
PubChem Substance ID
14799774, 14897685, 24137434, 44936800, 53367229, 53786994, 96025667, 103458633, 104053909, 128418830, 134342589, 135207230, 142938819, 144205825, 163620841, 163686169, 184824606, 198955457, 228053286, 251970949, 252166706
Target and Pathway
Target(s) High affinity interleukin-8 receptor B Target Info Modulator
High affinity interleukin-8 receptor A Target Info Modulator
KEGG Pathway Cytokine-cytokine receptor interaction
Chemokine signaling pathway
Endocytosis
Epithelial cell signaling in Helicobacter pylori infectionhsa04060:Cytokine-cytokine receptor interaction
Epithelial cell signaling in Helicobacter pylori infection
NetPath Pathway TNFalpha Signaling PathwayNetPath_14:IL2 Signaling Pathway
PANTHER Pathway Inflammation mediated by chemokine and cytokine signaling pathway
Interleukin signaling pathwayP00031:Inflammation mediated by chemokine and cytokine signaling pathway
Interleukin signaling pathway
Pathway Interaction Database IL8- and CXCR2-mediated signaling eventsil8cxcr1_pathway:IL8- and CXCR1-mediated signaling events
Reactome Chemokine receptors bind chemokines
G alpha (i) signalling eventsR-HSA-380108:Chemokine receptors bind chemokines
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
GPCRs, OtherWP455:GPCRs, Class A Rhodopsin-like
Differentiation Pathway
GPCRs, Other
References
Ref 537129New developments in immunosuppressive therapy for heart transplantation. Expert Opin Emerg Drugs. 2009 Mar;14(1):1-21.
Ref 543171(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8498).

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