Drug Information

Drug General Information
Drug ID
D0LJ0L
Former ID
DIB015250
Drug Name
Lu-AA47070
Synonyms
Adenosine A2a antagonists (Parkinson's disease), Lundbeck
Indication Parkinson's disease [ICD9: 332; ICD10:G20] Discontinued in Phase 1 [548653]
Company
H. Lundbeck A/S
Canonical SMILES
P(=O)(OCn1/c(=N/C(=O)c2cc(c(c(c2)F)NC(=O)CC(C)(C)C)F)/s<br />cc1)(O)O
Target and Pathway
Target(s) Adenosine A2a receptor Target Info Antagonist [531680]
KEGG Pathway Rap1 signaling pathway
Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Vascular smooth muscle contraction
Parkinson's disease
Alcoholism
Pathway Interaction Database HIF-2-alpha transcription factor network
PathWhiz Pathway Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
Reactome NGF-independant TRKA activation
Adenosine P1 receptors
G alpha (s) signalling events
Surfactant metabolism
WikiPathways Nucleotide GPCRs
Monoamine Transport
GPCRs, Class A Rhodopsin-like
NGF signalling via TRKA from the plasma membrane
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 548653Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800027391)
Ref 531680The novel adenosine A2A antagonist Lu AA47070 reverses the motor and motivational effects produced by dopamine D2 receptor blockade. Pharmacol Biochem Behav. 2012 Jan;100(3):498-505.

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