Drug Information

Drug General Information
Drug ID
D0L9SN
Former ID
DNC000989
Drug Name
NAN-190
Drug Type
Small molecular drug
Indication Discovery agent Terminated [542320], [544809]
Formula
C23H27N3O3
InChI
InChI=1S/C23H27N3O3/c1-29-21-11-5-4-10-20(21)25-16-14-24(15-17-25)12-6-7-13-26-22(27)18-8-2-3-9-19(18)23(26)28/h2-5,8-11H,6-7,12-17H2,1H3
InChIKey
SJDOMIRMMUGQQK-UHFFFAOYSA-N
CAS Number
CAS 149847-87-0
PubChem Compound ID
4431
PubChem Substance ID
5096910, 8152736, 11111535, 11113562, 14854322, 26751769, 29223528, 47959943, 48035313, 48110624, 50070708, 50104456, 80922047, 85209408, 85788301, 90341187, 103167522, 103856048, 103920452, 104306388, 106801846, 118489674, 124750067, 124880879, 124880880, 124880881, 126722888, 129243807, 135610579, 135650690, 136350487, 137144105, 143722439, 162222851, 162986222, 179235721, 203101922, 223536004, 224218878, 228359247, 250078615
Target and Pathway
Target(s) 5-hydroxytryptamine 1A receptor Target Info Antagonist [538050]
KEGG Pathway cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathway
Reactome Serotonin receptors
G alpha (i) signalling events
WikiPathways Serotonin HTR1 Group and FOS Pathway
SIDS Susceptibility Pathways
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 542320(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 73).
Ref 544809Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001193)
Ref 538050Influence of 5-HT1A receptor antagonism on plus-maze behaviour in mice. II. WAY 100635, SDZ 216-525 and NAN-190. Pharmacol Biochem Behav. 1997 Oct;58(2):593-603.

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