Drug Information

Drug General Information
Drug ID
D0L8OJ
Former ID
DNC010483
Drug Name
Alstiphyllanine D
Drug Type
Small molecular drug
Indication Discovery agent Investigative [530756]
Formula
C33H38N2O9
Canonical SMILES
CC=C1CN2C3CC1C(C45C3(N(C6=C4C=C(C=C6)OC)C)OC2C5)(COC(=O<br />)C7=CC(=C(C(=C7)OC)OC)OC)C(=O)OC
InChI
1S/C33H38N2O9/c1-8-18-16-35-26-14-21(18)31(30(37)42-7,17-43-29(36)19-11-24(39-4)28(41-6)25(12-19)40-5)32-15-27(35)44-33(26,32)34(2)23-10-9-20(38-3)13-22(23)32/h8-13,21,26-27H,14-17H2,1-7H3/b18-8-/t21-,26-,27-,31-,32-,33-/m0/s1
InChIKey
JIGZBLWURVFVNC-MPYFAWNJSA-N
PubChem Compound ID
45269680
Target and Pathway
Target(s) mRNA of sodium-glucosetransporter-2 Target Info Inhibitor [530756]
Sodium/glucose cotransporter 1 Target Info Inhibitor [530756]
KEGG Pathway Carbohydrate digestion and absorption
Bile secretion
Mineral absorption
PathWhiz Pathway Lactose Degradation
Trehalose Degradation
Reactome Hexose transport
Na+-dependent glucose transporters
Inositol transportersR-HSA-189200:Hexose transport
Inositol transporters
WikiPathways NRF2 pathway
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compoundsWP2884:NRF2 pathway
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
Metabolism of carbohydrates
References
Ref 530756Bioorg Med Chem. 2010 Mar 15;18(6):2152-8. Epub 2010 Feb 6.Alstiphyllanines E-H, picraline and ajmaline-type alkaloids from Alstonia macrophylla inhibiting sodium glucose cotransporter.
Ref 530756Bioorg Med Chem. 2010 Mar 15;18(6):2152-8. Epub 2010 Feb 6.Alstiphyllanines E-H, picraline and ajmaline-type alkaloids from Alstonia macrophylla inhibiting sodium glucose cotransporter.

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