Drug Information

Drug General Information
Drug ID
D0L8KJ
Former ID
DIB002837
Drug Name
Oglemilast
Synonyms
GRC-3886; Oglemilast (oral, COPD/asthma), Glenmark
Drug Type
Small molecular drug
Indication Asthma [ICD10:J45] Phase 2 [522312]
Company
Glenmark Pharmaceuticals Ltd
Formula
C20H13Cl2F2N3O5S
Canonical SMILES
c1(ccc2c(c1)c1c(o2)c(ccc1C(=O)Nc1c(cncc1Cl)Cl)OC(F)F)NS<br />(=O)(=O)C
CAS Number
CAS 778576-62-8
PubChem Compound ID
11387409
Target and Pathway
Target(s) CAMP-specific 3',5'-cyclic phosphodiesterase 4A Target Info Inhibitor [544060]
CAMP-specific 3',5'-cyclic phosphodiesterase 4B Target Info Inhibitor [544060]
Type IV phosphodiesterase Target Info Inhibitor [544060]
KEGG Pathway Purine metabolism
cAMP signaling pathway
Morphine addictionhsa00230:Purine metabolism
Morphine addiction
NetPath Pathway IL5 Signaling Pathway
IL2 Signaling Pathway
PathWhiz Pathway Purine Metabolism
Reactome DARPP-32 events
G alpha (s) signalling eventsR-HSA-180024:DARPP-32 events
G alpha (s) signalling events
WikiPathways G Protein Signaling PathwaysWP35:G Protein Signaling Pathways
Myometrial Relaxation and Contraction Pathways
Nuclear Receptors Meta-Pathway
Opioid SignallingWP35:G Protein Signaling Pathways
TSH signaling pathway
References
Ref 522312ClinicalTrials.gov (NCT00671073) Study To Assess Efficacy and Safety of Oglemilast in Patients With Chronic Obstructive Pulmonary Disease (COPD). U.S. National Institutes of Health.
Ref 544060Can the anti-inflammatory potential of PDE4 inhibitors be realized: guarded optimism or wishful thinking?. Br J Pharmacol. 2008 October; 155(3): 288-290.

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