Drug Information

Drug General Information
Drug ID
D0L7SY
Former ID
DIB000905
Drug Name
Delequamine hydrochloride
Synonyms
Delquamine; RS-15385-197; RS-15385-FP; RS-15385-FPh
Drug Type
Small molecular drug
Indication Male sexual disorders [ICD10:F52] Discontinued in Phase 3 [546534]
Company
Roche Bioscience
Formula
C18H27ClN2O3S
Canonical SMILES
S(=O)(=O)(N1[C@H]2C[C@@H]3N(C[C@H]2CCC1)CCc1c3ccc(c1)OC<br />)C.Cl
CAS Number
CAS 119942-75-5
PubChem Compound ID
168898
Target and Pathway
Target(s) Alpha-2C adrenergic receptor Target Info Modulator [534174]
KEGG Pathway cGMP-PKG signaling pathway
Neuroactive ligand-receptor interaction
PANTHER Pathway Alpha adrenergic receptor signaling pathway
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Reactome Adrenoceptors
Adrenaline signalling through Alpha-2 adrenergic receptor
Adrenaline,noradrenaline inhibits insulin secretion
G alpha (i) signalling events
G alpha (z) signalling events
Surfactant metabolism
WikiPathways Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Platelet Aggregation (Plug Formation)
Integration of energy metabolism
GPCR ligand binding
GPCR downstream signaling
References
Ref 546534Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800008832)
Ref 534174Modulation of sexual behaviour in the rat by a potent and selective alpha 2-adrenoceptor antagonist, delequamine (RS-15385-197). Br J Pharmacol. 1996 May;118(1):63-72.

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