Drug Information

Drug General Information
Drug ID
D0L5XG
Former ID
DIB015388
Drug Name
PF-4191834
Synonyms
PF-04191834
Drug Type
Small molecular drug
Indication Asthma [ICD10:J45] Phase 2 [523080]
Company
Pfizer Inc
Formula
C22H23N3O2S
Canonical SMILES
C1CC(CCO1)(C(=O)N)c1cc(ccc1)Sc1ccc(cc1)c1n(ncc1)C
PubChem Compound ID
24986635
Target and Pathway
Target(s) Arachidonate 5-lipoxygenase Target Info Inhibitor [530836]
BioCyc Pathway Aspirin-triggered lipoxin biosynthesis
Resolvin D biosynthesis
Leukotriene biosynthesis
Lipoxin biosynthesis
Aspirin triggered resolvin D biosynthesis
Aspirin triggered resolvin E biosynthesis
KEGG Pathway Arachidonic acid metabolism
Metabolic pathways
Serotonergic synapse
Ovarian steroidogenesis
Toxoplasmosis
NetPath Pathway IL4 Signaling Pathway
PathWhiz Pathway Arachidonic Acid Metabolism
WikiPathways Vitamin D Receptor Pathway
Arachidonic acid metabolism
Eicosanoid Synthesis
Selenium Micronutrient Network
References
Ref 523080ClinicalTrials.gov (NCT01147458) A Study Of The Safety And Efficacy Of PF-04191834 In Patients With Osteoarthritis Of The Knee. U.S. National Institutes of Health.
Ref 530836Pharmacology of PF-4191834, a novel, selective non-redox 5-lipoxygenase inhibitor effective in inflammation and pain. J Pharmacol Exp Ther. 2010 Jul;334(1):294-301.

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