Drug Information

Drug General Information
Drug ID
D0L1PQ
Former ID
DNC004988
Drug Name
3-(3-Pyridin-2-yl-pyrrol-1-yl)-benzonitrile
Drug Type
Small molecular drug
Indication Discovery agent Investigative [527190]
Formula
C16H11N3
Canonical SMILES
C1=CC=NC(=C1)C2=CN(C=C2)C3=CC=CC(=C3)C#N
InChI
1S/C16H11N3/c17-11-13-4-3-5-15(10-13)19-9-7-14(12-19)16-6-1-2-8-18-16/h1-10,12H
InChIKey
VWIHRRSEESXDSS-UHFFFAOYSA-N
PubChem Compound ID
10332109
Target and Pathway
Target(s) Metabotropic glutamate receptor 5 Target Info Inhibitor [527190]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Long-term potentiation
Retrograde endocannabinoid signaling
Glutamatergic synapse
Huntington's disease
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Metabotropic glutamate receptor group III pathway
Metabotropic glutamate receptor group I pathway
Endogenous cannabinoid signaling
Reactome G alpha (q) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)
WikiPathways Hypothetical Network for Drug Addiction
GPCRs, Class C Metabotropic glutamate, pheromone
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 527190J Med Chem. 2004 Sep 9;47(19):4645-8.Discovery of novel heteroarylazoles that are metabotropic glutamate subtype 5 receptor antagonists with anxiolytic activity.
Ref 527190J Med Chem. 2004 Sep 9;47(19):4645-8.Discovery of novel heteroarylazoles that are metabotropic glutamate subtype 5 receptor antagonists with anxiolytic activity.

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