Drug Information

Drug General Information
Drug ID
D0L0SF
Former ID
DIB020278
Drug Name
LY320954
Synonyms
PDSP2_001613; PDSP1_001629; LY-320954
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539136]
Formula
C21H26N4O3
InChI
InChI=1S/C21H26N4O3/c1-3-5-17-15(8-11-18(20(17)27)19(26)4-2)13-28-16-9-6-14(7-10-16)12-24-25-21(22)23/h6-12,27H,3-5,13H2,1-2H3,(H4,22,23,25)/b24-12+
InChIKey
TUJFUBGJRSXFHG-WYMPLXKRSA-N
PubChem Compound ID
10385240
PubChem Substance ID
15400642, 34104849, 47434908, 47657154, 76636316, 136351107
Target and Pathway
Target(s) 5-hydroxytryptamine 2A receptor Target Info Antagonist [534232]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Serotonergic synapse
Inflammatory mediator regulation of TRP channels
PANTHER Pathway 5HT2 type receptor mediated signaling pathway
Reactome Serotonin receptors
G alpha (q) signalling events
WikiPathways Serotonin Receptor 2 and STAT3 Signaling
Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
SIDS Susceptibility Pathways
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 539136(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 182).
Ref 534232A novel class of 5-HT2A receptor antagonists: aryl aminoguanidines. Life Sci. 1996;59(15):1259-68.

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