Drug Information

Drug General Information
Drug ID
D0L0MO
Former ID
DIB004340
Drug Name
Satigrel
Synonyms
E-5510
Drug Type
Small molecular drug
Indication Thromboembolism [ICD9: 437.6, 453, 671.5, 671.9; ICD10:I80-I82] Discontinued in Preregistration [544655]
Company
Eisai Co Ltd
Formula
C20H19NO4
Canonical SMILES
C(=C(C#N)CCC(=O)O)(c1ccc(cc1)OC)c1ccc(cc1)OC
CAS Number
CAS 111753-73-2
PubChem Compound ID
65913
Target and Pathway
Target(s) Thromboxane-A synthase Target Info Modulator [534205]
BioCyc Pathway C20 prostanoid biosynthesis
KEGG Pathway Arachidonic acid metabolism
Metabolic pathways
Platelet activation
PathWhiz Pathway Arachidonic Acid Metabolism
WikiPathways Prostaglandin Synthesis and Regulation
Arachidonic acid metabolism
Phase 1 - Functionalization of compounds
Eicosanoid Synthesis
References
Ref 544655Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000441)
Ref 534205Mechanisms of satigrel (E5510), a new anti-platelet drug, in inhibiting human platelet aggregation. Selectivity and potency against prostaglandin H synthases isozyme activities and phosphodiesterase isoform activities. Biol Pharm Bull. 1996 Jun;19(6):828-33.

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