Drug Information

Drug General Information
Drug ID
D0KV4Z
Former ID
DIB008978
Drug Name
CI-949
Drug Type
Small molecular drug
Indication Asthma [ICD10:J45] Discontinued in Phase 2 [544546]
Company
Dura Pharmaceuticals Inc
Formula
C26H34N10O5
Canonical SMILES
c1(n(c2c(c1OC(C)C)cc(cc2)OC)c1ccccc1)C(=O)Nc1nnn[nH]1.C<br />(=N)(NCCC[C@@H](C(=O)O)N)N
CAS Number
CAS 121530-58-3
PubChem Compound ID
159562
Target and Pathway
Target(s) Leukotriene B4 receptor 1 Target Info Modulator [528462]
KEGG Pathway Neuroactive ligand-receptor interaction
NetPath Pathway IL4 Signaling Pathway
Reactome Leukotriene receptors
G alpha (q) signalling events
WikiPathways Nucleotide GPCRs
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Spinal Cord Injury
GPCR ligand binding
GPCR downstream signaling
References
Ref 544546Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000104)
Ref 528462Inhibition of histamine, leukotriene C4/D4, and thromboxane B2 release from human leukocytes and human chopped lung mast cells by the allergic mediator release inhibitor, CI-949. J Allergy Clin Immunol. 1990 Dec;86(6 Pt 1):902-8.

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