Drug Information

Drug General Information
Drug ID
D0KL4K
Former ID
DIB020243
Drug Name
LSP4-2022
Drug Type
Small molecular drug
Indication Discovery agent Investigative [541811]
Formula
C13H18NO8P
InChI
InChI=1S/C13H18NO8P/c14-10(12(17)18)5-6-23(20,21)13(19)8-1-3-9(4-2-8)22-7-11(15)16/h1-4,10,13,19H,5-7,14H2,(H,15,16)(H,17,18)(H,20,21)/t10-,13?/m0/s1
InChIKey
BGOFVWMHMQISHB-NKUHCKNESA-N
PubChem Compound ID
71041983
PubChem Substance ID
163429707, 178103317, 194181129, 238963982
Target and Pathway
Target(s) mGlu6 receptor Target Info Agonist [531757]
Metabotropic glutamate receptor 4 Target Info Agonist [531757]
Metabotropic glutamate receptor 7 Target Info Agonist [531757]
KEGG Pathway Neuroactive ligand-receptor interaction
Glutamatergic synapse
Taste transductionhsa04080:Neuroactive ligand-receptor interaction
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Metabotropic glutamate receptor group III pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Metabotropic glutamate receptor group III pathway
Reactome G alpha (i) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)R-HSA-418594:G alpha (i) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)
WikiPathways GPCRs, Class C Metabotropic glutamate, pheromone
GPCR ligand binding
GPCR downstream signalingWP501:GPCRs, Class C Metabotropic glutamate, pheromone
GPCR downstream signaling
References
Ref 541811(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6706).
Ref 531757A novel selective metabotropic glutamate receptor 4 agonist reveals new possibilities for developing subtype selective ligands with therapeutic potential. FASEB J. 2012 Apr;26(4):1682-93.

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