Drug Information

Drug General Information
Drug ID
D0KK4C
Former ID
DNC011575
Drug Name
2-[2-(1H-Imidazol-4-yl)-cyclopropyl]-ethylamine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [526614]
Formula
C8H13N3
Canonical SMILES
C1C(C1C2=CN=CN2)CCN
InChI
1S/C8H13N3/c9-2-1-6-3-7(6)8-4-10-5-11-8/h4-7H,1-3,9H2,(H,10,11)/t6-,7+/m1/s1
InChIKey
OTBYLNCJHFPRTL-RQJHMYQMSA-N
PubChem Compound ID
10154137
Target and Pathway
Target(s) Histamine H3 receptor Target Info Inhibitor [526614]
KEGG Pathway Neuroactive ligand-receptor interaction
Reactome Histamine receptors
G alpha (i) signalling events
WikiPathways Monoamine Transport
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 526614J Med Chem. 2003 May 8;46(10):1980-8.Cyclopropane-based conformational restriction of histamine. (1S,2S)-2-(2-aminoethyl)-1-(1H-imidazol-4-yl)cyclopropane, a highly selective agonist for the histamine H3 receptor, having a cis-cyclopropane structure.
Ref 526614J Med Chem. 2003 May 8;46(10):1980-8.Cyclopropane-based conformational restriction of histamine. (1S,2S)-2-(2-aminoethyl)-1-(1H-imidazol-4-yl)cyclopropane, a highly selective agonist for the histamine H3 receptor, having a cis-cyclopropane structure.

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