Drug Information

Drug General Information
Drug ID
D0K8KJ
Former ID
DIB016419
Drug Name
DuP-129
Synonyms
ACAT inhibitors, Du Pont
Indication Hypercholesterolemia [ICD10:E78] Terminated [545519]
Company
Bristol-Myers Squibb Pharma Co
Canonical SMILES
C1(N=C(N([C@@H]1CC(=O)C1CCCCC1)C)c1ccc(cc1)F)(C(F)(F)F)<br />C(F)(F)F
Target and Pathway
Target(s) Liver carboxylesterase Target Info Inhibitor [543651]
KEGG Pathway Drug metabolism - other enzymes
Metabolic pathways
Pathway Interaction Database E2F transcription factor network
WikiPathways NRF2 pathway
Nuclear Receptors Meta-Pathway
Heroin metabolism
Irinotecan Pathway
Fluoropyrimidine Activity
Phase I biotransformations, non P450
References
Ref 545519Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003587)
Ref 543651(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2592).

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