Drug Information

Drug General Information
Drug ID
D0K8DZ
Former ID
DIB021201
Drug Name
VUF 5207
Synonyms
VUF-5207; VUF5207
Drug Type
Small molecular drug
Indication Discovery agent Investigative [538759]
Formula
C10H19N3
InChI
InChI=1S/C10H19N3/c1-13(2)7-5-3-4-6-10-8-11-9-12-10/h8-9H,3-7H2,1-2H3,(H,11,12)
InChIKey
MVHBNHUOEFGIBK-UHFFFAOYSA-N
PubChem Compound ID
11672774
PubChem Substance ID
16776623, 47731180, 48179657, 50076871, 77030825, 103483731, 135262461, 135651312, 136351931
Target and Pathway
Target(s) Histamine H3 receptor Target Info Agonist [526200]
KEGG Pathway Neuroactive ligand-receptor interaction
Reactome Histamine receptors
G alpha (i) signalling events
WikiPathways Monoamine Transport
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 538759(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1245).
Ref 526200Constitutive activity of histamine h(3) receptors stably expressed in SK-N-MC cells: display of agonism and inverse agonism by H(3) antagonists. J Pharmacol Exp Ther. 2001 Dec;299(3):908-14.

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