Drug Information

Drug General Information
Drug ID
D0K7XM
Former ID
DNC006212
Drug Name
APLYSAMINE
Drug Type
Small molecular drug
Indication Discovery agent Investigative [529632]
Formula
C15H24Br2N2O
Canonical SMILES
CN(C)CCCOC1=C(C=C(C=C1Br)CCN(C)C)Br
InChI
1S/C15H24Br2N2O/c1-18(2)7-5-9-20-15-13(16)10-12(11-14(15)17)6-8-19(3)4/h10-11H,5-9H2,1-4H3
InChIKey
LWENJEAGCYZOBC-UHFFFAOYSA-N
PubChem Compound ID
362025
Target and Pathway
Target(s) Histamine H3 receptor Target Info Inhibitor [529632]
KEGG Pathway Neuroactive ligand-receptor interaction
Reactome Histamine receptors
G alpha (i) signalling events
WikiPathways Monoamine Transport
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 529632J Med Chem. 2008 Sep 11;51(17):5423-30. Epub 2008 Aug 7.The alkaloid conessine and analogues as potent histamine H3 receptor antagonists.
Ref 529632J Med Chem. 2008 Sep 11;51(17):5423-30. Epub 2008 Aug 7.The alkaloid conessine and analogues as potent histamine H3 receptor antagonists.

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