Drug Information

Drug General Information
Drug ID
D0K4UW
Former ID
DIB014304
Drug Name
Imitrodast
Synonyms
Logran; CS-518; RS-5186
Drug Type
Small molecular drug
Indication Asthma [ICD10:J45] Discontinued in Phase 2 [544584]
Company
Sankyo Co Ltd
Formula
C13H12N2O2S
Canonical SMILES
c12c(cc(s1)Cn1ccnc1)CCC(=C2)C(=O)[O-].[Na+]
CAS Number
CAS 113817-57-5
PubChem Compound ID
65922
Target and Pathway
Target(s) Thromboxane-A synthase Target Info Inhibitor [533430]
BioCyc Pathway C20 prostanoid biosynthesis
KEGG Pathway Arachidonic acid metabolism
Metabolic pathways
Platelet activation
PathWhiz Pathway Arachidonic Acid Metabolism
WikiPathways Prostaglandin Synthesis and Regulation
Arachidonic acid metabolism
Phase 1 - Functionalization of compounds
Eicosanoid Synthesis
References
Ref 544584Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000225)
Ref 533430RS-5186, a novel thromboxane synthetase inhibitor with a potent and extended duration of action. Thromb Res. 1988 Sep 1;51(5):507-20.

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