Drug Information

Drug General Information
Drug ID
D0K4GK
Former ID
DIB018533
Drug Name
22R-hydroxycholesterol
Synonyms
22beta-hydroxycholesterol; 22R-OHC
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539787]
Formula
C27H46O2
InChI
InChI=1S/C27H46O2/c1-17(2)6-11-25(29)18(3)22-9-10-23-21-8-7-19-16-20(28)12-14-26(19,4)24(21)13-15-27(22,23)5/h7,17-18,20-25,28-29H,6,8-16H2,1-5H3/t18-,20-,21-,22+,23-,24-,25+,26-,27+/m0/s1
InChIKey
RZPAXNJLEKLXNO-GFKLAVDKSA-N
PubChem Compound ID
167685
PubChem Substance ID
7855, 7983970, 10256555, 17501138, 24895852, 46241149, 49688252, 57351298, 75005942, 103114776, 103162244, 103428723, 113461277, 123080470, 126524977, 127346295, 135123118, 135651388, 135764294, 137109197, 139022589, 140154466, 160645367, 162226561, 162817550, 172829375, 179293231, 184582401, 226478367, 242081676
Target and Pathway
Target(s) Oxysterols receptor LXR-beta Target Info Agonist [534255]
Oxysterols receptor LXR-alpha Target Info Agonist [534255]
Bile acid receptor Target Info Agonist [527938]
KEGG Pathway PPAR signaling pathway
Non-alcoholic fatty liver disease (NAFLD)
Hepatitis Chsa04976:Bile secretion
Pathway Interaction Database RXR and RAR heterodimerization with other nuclear receptorrxr_vdr_pathway:RXR and RAR heterodimerization with other nuclear receptorrxr_vdr_pathway:RXR and RAR heterodimerization with other nuclear receptor
Reactome Nuclear Receptor transcription pathwayR-HSA-159418:Recycling of bile acids and salts
PPARA activates gene expression
Endogenous sterols
WikiPathways SREBP signalling
Nuclear ReceptorsWP299:Nuclear Receptors in Lipid Metabolism and Toxicity
Nuclear Receptors Meta-Pathway
PPAR Alpha Pathway
Liver X Receptor Pathway
Adipogenesis
SREBF and miR33 in cholesterol and lipid homeostasis
Farnesoid X Receptor Pathway
Drug Induction of Bile Acid Pathway
References
Ref 539787(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2742).
Ref 527938Oxysterol 22(R)-hydroxycholesterol induces the expression of the bile salt export pump through nuclear receptor farsenoid X receptor but not liver X receptor. J Pharmacol Exp Ther. 2006 Apr;317(1):317-25. Epub 2005 Dec 21.
Ref 534255An oxysterol signalling pathway mediated by the nuclear receptor LXR alpha. Nature. 1996 Oct 24;383(6602):728-31.

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