Drug Information

Drug General Information
Drug ID
D0K2BQ
Former ID
DNC011581
Drug Name
BRL-61063
Drug Type
Small molecular drug
Indication Allergy [ICD9: 995.3; ICD10:T78.4] Discontinued in Phase 2 [545780]
Formula
C13H17N5O2
Canonical SMILES
C1CC1CN2C3=C(C(=O)N(C2=O)CC4CC4)NC(=N3)N
InChI
1S/C13H17N5O2/c14-12-15-9-10(16-12)17(5-7-1-2-7)13(20)18(11(9)19)6-8-3-4-8/h7-8H,1-6H2,(H3,14,15,16)
InChIKey
KSPYMJJKQMWWNB-UHFFFAOYSA-N
PubChem Compound ID
71356
Target and Pathway
Target(s) Adenosine A1 receptor Target Info Inhibitor [533908]
CGMP-specific 3',5'-cyclic phosphodiesterase Target Info Inhibitor [533908]
KEGG Pathway cGMP-PKG signaling pathway
cAMP signaling pathway
Sphingolipid signaling pathway
Neuroactive ligand-receptor interaction
Morphine addictionhsa00230:Purine metabolism
NetPath Pathway TCR Signaling Pathway
RANKL Signaling PathwayNetPath_7:TGF_beta_Receptor Signaling Pathway
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Reactome Adenosine P1 receptors
G alpha (i) signalling eventsR-HSA-418457:cGMP effects
WikiPathways Nucleotide GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 545780Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800004678)
Ref 533908J Med Chem. 1994 Feb 18;37(4):476-85.Inhibition of cyclic nucleotide phosphodiesterase by derivatives of 1,3-bis(cyclopropylmethyl)xanthine.

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