Drug Information

Drug General Information
Drug ID
D0K1SZ
Former ID
DNC010191
Drug Name
Norcisapride
Drug Type
Small molecular drug
Indication Gastroesophageal reflux disease [ICD9: 140-229, 530; ICD10:K21] Discontinued in Phase 2 [546263]
Formula
C14H20ClN3O3
Canonical SMILES
COC1CNCCC1NC(=O)C2=CC(=C(C=C2OC)N)Cl
InChI
1S/C14H20ClN3O3/c1-20-12-6-10(16)9(15)5-8(12)14(19)18-11-3-4-17-7-13(11)21-2/h5-6,11,13,17H,3-4,7,16H2,1-2H3,(H,18,19)
InChIKey
OMLDMGPCWMBPAN-UHFFFAOYSA-N
PubChem Compound ID
3019427
Target and Pathway
Target(s) 5-hydroxytryptamine 4 receptor Target Info Inhibitor [530330]
5-hydroxytryptamine receptor 3A Target Info Inhibitor [530330]
KEGG Pathway Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapsehsa04726:Serotonergic synapse
NetPath Pathway IL2 Signaling Pathway
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT4 type receptor mediated signaling pathwayP04375:5HT3 type receptor mediated signaling pathway
PathWhiz Pathway Excitatory Neural Signalling Through 5-HTR 4 and Serotonin
Reactome Serotonin receptors
G alpha (s) signalling eventsR-HSA-975298:Ligand-gated ion channel transport
WikiPathways Serotonin Receptor 4/6/7 and NR3C Signaling
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signalingWP706:SIDS Susceptibility Pathways
Iron uptake and transport
References
Ref 546263Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800007174)
Ref 530330Bioorg Med Chem Lett. 2009 Oct 1;19(19):5679-83. Epub 2009 Aug 8.mu-Opioid/5-HT4 dual pharmacologically active agents-efforts towards an effective opioid analgesic with less GI and respiratory side effects (Part I).

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