Drug Information

Drug General Information
Drug ID
D0K1OA
Former ID
DIB005715
Drug Name
D-4418
Drug Type
Small molecular drug
Indication Cutaneous T-cell lymphoma [ICD9: 202.1, 202.2; ICD10:C84.0, C84.1] Discontinued in Phase 1 [546370]
Company
Chiroscience R&D Ltd
Formula
C16H11Cl2N3O2
Canonical SMILES
C(=O)(c1c2c(nccc2)c(cc1)OC)Nc1c(ncc(c1)Cl)Cl
CAS Number
CAS 257892-34-5
PubChem Compound ID
9928260
Target and Pathway
Target(s) CAMP-specific 3',5'-cyclic phosphodiesterase 4A Target Info Inhibitor [529616]
Type IV phosphodiesterase Target Info Inhibitor [529616]
CAMP-specific 3',5'-cyclic phosphodiesterase 4B Target Info Inhibitor [529616]
KEGG Pathway Purine metabolism
cAMP signaling pathway
Morphine addictionhsa00230:Purine metabolism
Morphine addiction
NetPath Pathway IL5 Signaling Pathway
IL2 Signaling Pathway
PathWhiz Pathway Purine Metabolism
Reactome DARPP-32 events
G alpha (s) signalling eventsR-HSA-180024:DARPP-32 events
G alpha (s) signalling events
WikiPathways G Protein Signaling PathwaysWP35:G Protein Signaling Pathways
Myometrial Relaxation and Contraction Pathways
TSH signaling pathwayWP35:G Protein Signaling Pathways
Nuclear Receptors Meta-Pathway
Opioid Signalling
References
Ref 546370Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800007757)
Ref 529616Can the anti-inflammatory potential of PDE4 inhibitors be realized: guarded optimism or wishful thinking. Br J Pharmacol. 2008 Oct;155(3):288-90.

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