Drug Information

Drug General Information
Drug ID
D0K0FI
Former ID
DIB018699
Drug Name
7-methoxy-1-naphthylpiperazine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [541264]
Formula
C11H25NO3Si2
InChI
InChI=1S/C11H25NO3Si2/c1-16(2,3)17(4,5)7-6-12-11(13)15-9-10-8-14-10/h10H,6-9H2,1-5H3,(H,12,13)
InChIKey
RMYUPIFLALKWOD-UHFFFAOYSA-N
PubChem Compound ID
14533720
PubChem Substance ID
32614945, 129152605, 135649861, 234878097
Target and Pathway
Target(s) 5-hydroxytryptamine 1B receptor Target Info Agonist [534528]
5-hydroxytryptamine 1D receptor Target Info Agonist [534528]
5-hydroxytryptamine 1A receptor Target Info Agonist [534528]
KEGG Pathway cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapsehsa04024:cAMP signaling pathway
Serotonergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathway
Reactome Serotonin receptors
G alpha (i) signalling eventsR-HSA-390666:Serotonin receptors
G alpha (i) signalling events
WikiPathways Serotonin HTR1 Group and FOS Pathway
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signalingWP722:Serotonin HTR1 Group and FOS Pathway
SIDS Susceptibility Pathways
GPCR downstream signaling
References
Ref 541264(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6).
Ref 534528J Med Chem. 1997 Nov 21;40(24):3974-8.5-HT1B receptor antagonist properties of novel arylpiperazide derivatives of 1-naphthylpiperazine.

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