Drug Information

Drug General Information
Drug ID
D0J7EP
Former ID
DNCL001990
Drug Name
AVN 397
Indication Alzheimer disease; Anxiety disorder [ICD9: 331, 300, 311; ICD10:G30, F32, F40-F42] Discontinued in Phase 2 [549022]
Company
Avineuro Pharmaceuticals
Target and Pathway
Target(s) 5-hydroxytryptamine 6 receptor Target Info Antagonist [544229]
KEGG Pathway Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
PathWhiz Pathway Excitatory Neural Signalling Through 5-HTR 6 and Serotonin
Reactome Serotonin receptors
G alpha (s) signalling events
WikiPathways Serotonin Receptor 4/6/7 and NR3C Signaling
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 549022Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800031584)
Ref 544229Latrepirdine, a potential novel treatment for Alzheimer's disease and Huntington's chorea. Curr Opin Investig Drugs. 2010 January; 11(1): 80-91.

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