Drug Information

Drug General Information
Drug ID
D0J6WX
Former ID
DNAP001493
Drug Name
Flutropium bromide
Synonyms
Flubron (TN)
Drug Type
Small molecular drug
Indication Cough [ICD9: 786.2; ICD10:R05] Approved [551871]
Formula
C24H29BrFNO3
Canonical SMILES
C[N+]1(C2CCC1CC(C2)OC(=O)C(C3=CC=CC=C3)(C4=CC=CC=C4)O)C<br />CF.[Br-]
InChI
1S/C24H29FNO3.BrH/c1-26(15-14-25)20-12-13-21(26)17-22(16-20)29-23(27)24(28,18-8-4-2-5-9-18)19-10-6-3-7-11-19;/h2-11,20-22,28H,12-17H2,1H3;1H/q+1;/p-1/t20-,21-,22?,26?;/m1./s1
InChIKey
FNUZASGZEHGWQM-VASKBONBSA-M
PubChem Compound ID
71962
PubChem Substance ID
43128208, 50058777, 75850144, 92720019, 103071136, 103078201, 104351751, 117370135, 126620340, 126657732, 126668346, 162887728, 198981009, 223677209, 227838672, 249581705
Target and Pathway
Target(s) Muscarinic acetylcholine receptor M5 Target Info Modulator [536361]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Cholinergic synapse
Regulation of actin cytoskeleton
PANTHER Pathway Alzheimer disease-amyloid secretase pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Reactome Muscarinic acetylcholine receptors
G alpha (q) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
Regulation of Actin Cytoskeleton
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 536361Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. Epub 2007 Feb 20.

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