Drug Information

Drug General Information
Drug ID
D0J5QW
Former ID
DIB006567
Drug Name
ON-579
Drug Type
Small molecular drug
Indication Asthma [ICD10:J45] Terminated [545526]
Company
Taisho Pharmaceutical Co Ltd
Formula
C16H14ClF2NO5S2
Canonical SMILES
S(=O)(=O)(c1ccc(cc1)Cl)NCCSc1cc(c(c(c1)F)OCC(=O)O)F
CAS Number
CAS 141286-14-8
PubChem Compound ID
192308
Target and Pathway
Target(s) Thromboxane A2 receptor Target Info Modulator [533593]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Platelet activation
Reactome Prostanoid ligand receptors
G alpha (q) signalling events
G alpha (12/13) signalling events
Thromboxane signalling through TP receptor
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Small Ligand GPCRs
Signal amplification
GPCR ligand binding
GPCR downstream signaling
References
Ref 545526Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003601)
Ref 533593The effect of a TXA2 receptor antagonist ON-579 on experimental allergic reactions. Prostaglandins Leukot Essent Fatty Acids. 1995 Aug;53(2):123-33.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Tang and Dr. Zhang.