Drug Information

Drug General Information
Drug ID
D0J0JC
Former ID
DIB001121
Drug Name
FRG-8701
Drug Type
Small molecular drug
Indication Stomach ulcer [ICD10:K25-K27] Terminated [530445]
Company
Fujirebio KK
Formula
C22H30N2O4S
Canonical SMILES
S(=O)(CC(=O)NCCCOc1cc(CN2CCCCC2)ccc1)Cc1occc1
CAS Number
CAS 108498-50-6
PubChem Compound ID
130145
Target and Pathway
Target(s) Histamine H2 receptor Target Info Modulator [530445]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gastric acid secretion
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Histamine H2 receptor mediated signaling pathway
PathWhiz Pathway Intracellular Signalling Through Histamine H2 Receptor and Histamine
Gastric Acid Production
Reactome Histamine receptors
G alpha (s) signalling events
WikiPathways Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Secretion of Hydrochloric Acid in Parietal Cells
GPCR ligand binding
GPCR downstream signaling
References
Ref 530445Effects of FRG-8701 on gastric acid secretion, gastric mucosal lesions by necrotizing agents and experimental gastric or duodenal ulcer in rats. Jpn J Pharmacol. 1990 Nov;54(3):277-85.
Ref 530445Effects of FRG-8701 on gastric acid secretion, gastric mucosal lesions by necrotizing agents and experimental gastric or duodenal ulcer in rats. Jpn J Pharmacol. 1990 Nov;54(3):277-85.

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