Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0IO8J
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| Former ID |
DNC006125
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| Drug Name |
2-methyl-6-(phenylethynyl)pyridine
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent | Investigative | [530473] | ||
| Formula |
C14H11N
|
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| Canonical SMILES |
CC1=CC=CC(=N1)C#CC2=CC=CC=C2
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| InChI |
1S/C14H11N/c1-12-6-5-9-14(15-12)11-10-13-7-3-2-4-8-13/h2-9H,1H3
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| InChIKey |
NEWKHUASLBMWRE-UHFFFAOYSA-N
|
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Metabotropic glutamate receptor 5 | Target Info | Inhibitor | [530473] | |
| Metabotropicglutamate receptor 1 | Target Info | Inhibitor | [531019] | ||
| PANTHER Pathway | Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway | ||||
| Metabotropic glutamate receptor group III pathway | |||||
| Metabotropic glutamate receptor group I pathway | |||||
| Endogenous cannabinoid signalingP00027:Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway | |||||
| Endogenous cannabinoid signaling | |||||
| References | |||||
| Ref 530473 | Bioorg Med Chem Lett. 2009 Dec 1;19(23):6623-6. Epub 2009 Oct 9.Discovery and SAR of 6-substituted-4-anilinoquinazolines as non-competitive antagonists of mGlu5. | ||||
| Ref 531019 | Bioorg Med Chem Lett. 2010 Aug 1;20(15):4371-5. Epub 2010 Jun 17.Carbamoyloximes as novel non-competitive mGlu5 receptor antagonists. | ||||
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