Drug Information

Drug General Information
Drug ID
D0I7MW
Former ID
DNC006983
Drug Name
JWH-244
Drug Type
Small molecular drug
Indication Discovery agent Investigative [528355]
Formula
C27H27NO
Canonical SMILES
CCCCCN1C=C(C=C1C2=CC=C(C=C2)C)C(=O)C3=CC=CC4=CC=CC=C43
InChI
1S/C27H27NO/c1-3-4-7-17-28-19-23(18-26(28)22-15-13-20(2)14-16-22)27(29)25-12-8-10-21-9-5-6-11-24(21)25/h5-6,8-16,18-19H,3-4,7,17H2,1-2H3
InChIKey
RZASCFFZBHYWDH-UHFFFAOYSA-N
PubChem Compound ID
44418345
Target and Pathway
Target(s) Cannabinoid receptor 1 Target Info Inhibitor [528355]
Cannabinoid receptor 2 Target Info Inhibitor [528355]
KEGG Pathway Rap1 signaling pathway
Neuroactive ligand-receptor interaction
Retrograde endocannabinoid signalinghsa04080:Neuroactive ligand-receptor interaction
PANTHER Pathway Endogenous cannabinoid signaling
Pathway Interaction Database N-cadherin signaling events
Reactome Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling eventsR-HSA-373076:Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Small Ligand GPCRs
BDNF signaling pathway
GPCR ligand binding
GPCR downstream signaling
GPCRs, OtherWP455:GPCRs, Class A Rhodopsin-like
References
Ref 528355Bioorg Med Chem Lett. 2006 Oct 15;16(20):5432-5. Epub 2006 Aug 4.1-Alkyl-2-aryl-4-(1-naphthoyl)pyrroles: new high affinity ligands for the cannabinoid CB1 and CB2 receptors.
Ref 528355Bioorg Med Chem Lett. 2006 Oct 15;16(20):5432-5. Epub 2006 Aug 4.1-Alkyl-2-aryl-4-(1-naphthoyl)pyrroles: new high affinity ligands for the cannabinoid CB1 and CB2 receptors.

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