Drug Information

Drug General Information
Drug ID
D0I5TL
Former ID
DCL000032
Drug Name
ADX-48621
Drug Type
Small molecular drug
Indication Mood disorder [ICD10:F30-F39] Phase 2 [523431], [541593]
Company
Addex Pharma.
Formula
C16H12FN3
InChI
InChI=1S/C16H12FN3/c17-13-8-9-16-19-15(12-20(16)11-13)7-2-1-5-14-6-3-4-10-18-14/h3-4,6,8-12H,2,7H2
InChIKey
LZXMUJCJAWVHPZ-UHFFFAOYSA-N
PubChem Compound ID
44557636
PubChem Substance ID
87241159, 97125579, 135275203, 152258611, 160647446, 164129961, 164160580, 178103068, 186007060, 198990098, 202536041, 226477943, 246940972, 252478462
Target and Pathway
Target(s) Metabotropic glutamate receptor 5 Target Info Modulator [550205]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Long-term potentiation
Retrograde endocannabinoid signaling
Glutamatergic synapse
Huntington's disease
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Metabotropic glutamate receptor group III pathway
Metabotropic glutamate receptor group I pathway
Endogenous cannabinoid signaling
Reactome G alpha (q) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)
WikiPathways Hypothetical Network for Drug Addiction
GPCRs, Class C Metabotropic glutamate, pheromone
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 523431ClinicalTrials.gov (NCT01336088) ADX48621 for the Treatment of Levodopa Induced Dyskinesia in Patients With Parkinson's Disease. U.S. National Institutes of Health.
Ref 541593(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6452).
Ref 550205Pipeline of Addex Pharma. Addex Pharma. 2009.

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