Drug Information

Drug General Information
Drug ID
D0I5CT
Former ID
DIB018848
Drug Name
amthamine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [540628]
Formula
C6H11N3S
InChI
InChI=1S/C6H11N3S/c1-4-5(2-3-7)10-6(8)9-4/h2-3,7H2,1H3,(H2,8,9)
InChIKey
LHVRFUVVRXGZPV-UHFFFAOYSA-N
PubChem Compound ID
126688
PubChem Substance ID
7463560, 7978705, 10241626, 11113633, 14772393, 26751833, 29306178, 49846695, 53728491, 57341870, 85177274, 85208949, 85788610, 103245318, 104364188, 128491446, 132554051, 135083765, 137006440, 163124491, 164847658, 172912830, 174527483, 178100851, 184596032, 204380233, 226728866
Target and Pathway
Target(s) Histamine H2 receptor Target Info Agonist [529861]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gastric acid secretion
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Histamine H2 receptor mediated signaling pathway
PathWhiz Pathway Intracellular Signalling Through Histamine H2 Receptor and Histamine
Gastric Acid Production
Reactome Histamine receptors
G alpha (s) signalling events
WikiPathways Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Secretion of Hydrochloric Acid in Parietal Cells
GPCR ligand binding
GPCR downstream signaling
References
Ref 540628(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4025).
Ref 529861N(G)-acylated aminothiazolylpropylguanidines as potent and selective histamine H(2) receptor agonists. ChemMedChem. 2009 Feb;4(2):232-40.

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