Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0I3WC
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| Former ID |
DIB000358
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| Drug Name |
RO-4929097
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| Drug Type |
Small molecular drug
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| Company |
Roche
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| Formula |
C22H20F5N3O3
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| InChI |
InChI=1S/C22H20F5N3O3/c1-20(2,18(32)28-11-21(23,24)22(25,26)27)19(33)30-16-14-9-4-3-7-12(14)13-8-5-6-10-15(13)29-17(16)31/h3-10,16H,11H2,1-2H3,(H,28,32)(H,29,31)(H,30,33)/t16-/m0/s1
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| InChIKey |
OJPLJFIFUQPSJR-INIZCTEOSA-N
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| PubChem Compound ID | |||||
| PubChem Substance ID |
104253224, 121143589, 124757349, 125164153, 135323407, 135727396, 136348257, 136349997, 136367552, 136367801, 137276006, 137710929, 152258320, 160647159, 162011370, 162037674, 162202738, 163907988, 174006710, 174530815, 178103910, 184819500, 198939144, 223705127, 223929894, 227593850, 243630441, 252110184, 252162573, 252216215
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| Target and Pathway | |||||
| Target(s) | Gamma-secretase | Target Info | Modulator | [531882] | |
| KEGG Pathway | Notch signaling pathway | ||||
| Alzheimer's disease | |||||
| Reactome | Nuclear signaling by ERBB4 | ||||
| Regulated proteolysis of p75NTR | |||||
| NRIF signals cell death from the nucleus | |||||
| Activated NOTCH1 Transmits Signal to the Nucleus | |||||
| Constitutive Signaling by NOTCH1 PEST Domain Mutants | |||||
| Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | |||||
| NOTCH2 Activation and Transmission of Signal to the Nucleus | |||||
| EPH-ephrin mediated repulsion of cells | |||||
| References | |||||
| Ref 531882 | Phase I study of RO4929097, a gamma secretase inhibitor of Notch signaling, in patients with refractory metastatic or locally advanced solid tumors. J Clin Oncol. 2012 Jul 1;30(19):2348-53. | ||||
| Ref 542361 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7338). | ||||
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