Drug Information

Drug General Information
Drug ID
D0I3TU
Former ID
DIB006842
Drug Name
MK-7246
Synonyms
IDDBCP261213; IDDBCP271467
Drug Type
Small molecular drug
Indication Respiratory disease [ICD10:J00-J99] Phase 1 [548999]
Company
Merck & Co Inc
Formula
C21H21FN2O4S
Canonical SMILES
c1ccc2c(c1)n1c(c2CC(=O)O)CC[C@H](C1)N(S(=O)(=O)c1ccc(cc<br />1)F)C
PubChem Compound ID
45268455
Target and Pathway
Target(s) Putative G-protein coupled receptor 44 Target Info Modulator [531277]
Reactome Prostanoid ligand receptors
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 548999Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800031315)
Ref 531277Discovery of MK-7246, a selective CRTH2 antagonist for the treatment of respiratory diseases. Bioorg Med Chem Lett. 2011 Jan 1;21(1):288-93.

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