Drug Information

Drug General Information
Drug ID
D0I2MU
Former ID
DIB018598
Drug Name
3-isobutyl-8-pyrrolidinoxanthine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [467722]
Formula
C13H19N5O2
InChI
InChI=1S/C13H19N5O2/c1-8(2)7-18-10-9(11(19)16-13(18)20)14-12(15-10)17-5-3-4-6-17/h8H,3-7H2,1-2H3,(H,14,15)(H,16,19,20)
InChIKey
KHQOTPZSYMSVHB-UHFFFAOYSA-N
PubChem Compound ID
10221256
PubChem Substance ID
15222114, 22609941, 40335745, 78814027, 135650407, 143298146, 224274870, 229016387, 248309659
Target and Pathway
Target(s) Adenosine A2b receptor Target Info Antagonist [526188]
KEGG Pathway Rap1 signaling pathway
Calcium signaling pathway
Neuroactive ligand-receptor interaction
Vascular smooth muscle contraction
Alcoholism
NetPath Pathway TGF_beta_Receptor Signaling Pathway
TCR Signaling Pathway
Pathway Interaction Database C-MYB transcription factor network
PathWhiz Pathway Intracellular Signalling Through Adenosine Receptor A2b and Adenosine
Reactome Adenosine P1 receptors
G alpha (s) signalling events
Surfactant metabolism
WikiPathways Nucleotide GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 467722(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 447).
Ref 526188Inhibition of human mast cell activation with the novel selective adenosine A(2B) receptor antagonist 3-isobutyl-8-pyrrolidinoxanthine (IPDX)(2). Biochem Pharmacol. 2001 Nov 1;62(9):1163-73.

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