Drug Information

Drug General Information
Drug ID
D0I2AF
Former ID
DNC010730
Drug Name
2-phenyl-2H-benzo[d][1,2,3]triazole-4-carboxamide
Drug Type
Small molecular drug
Indication Discovery agent Investigative [530485]
Formula
C13H10N4O
Canonical SMILES
C1=CC=C(C=C1)N2N=C3C=CC=C(C3=N2)C(=O)N
InChI
1S/C13H10N4O/c14-13(18)10-7-4-8-11-12(10)16-17(15-11)9-5-2-1-3-6-9/h1-8H,(H2,14,18)
InChIKey
LALFCNWFYNSGHS-UHFFFAOYSA-N
PubChem Compound ID
44549505
Target and Pathway
Target(s) Poly [ADP-ribose] polymerase-1 Target Info Inhibitor [530485]
KEGG Pathway Base excision repair
NF-kappa B signaling pathway
PANTHER Pathway FAS signaling pathway
Pathway Interaction Database Integrin-linked kinase signaling
Caspase Cascade in Apoptosis
Notch-mediated HES/HEY network
Reactome Dual Incision in GG-NER
WikiPathways FAS pathway and Stress induction of HSP regulation
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
Nanoparticle triggered regulated necrosis
Corticotropin-releasing hormone
References
Ref 530485J Med Chem. 2009 Nov 26;52(22):7170-85.Discovery of 2-{4-[(3S)-piperidin-3-yl]phenyl}-2H-indazole-7-carboxamide (MK-4827): a novel oral poly(ADP-ribose)polymerase (PARP) inhibitor efficacious in BRCA-1 and -2 mutant tumors.
Ref 530485J Med Chem. 2009 Nov 26;52(22):7170-85.Discovery of 2-{4-[(3S)-piperidin-3-yl]phenyl}-2H-indazole-7-carboxamide (MK-4827): a novel oral poly(ADP-ribose)polymerase (PARP) inhibitor efficacious in BRCA-1 and -2 mutant tumors.

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