Drug Information

Drug General Information
Drug ID
D0I0GM
Former ID
DIB004728
Drug Name
Daxalipram
Synonyms
Mesopram; SH-636; ZK-117137; PDE 4 inhibitor (multiple sclerosis), Schering AG
Indication Multiple scierosis [ICD9: 340; ICD10:G35] Discontinued in Phase 2 [547377]
Company
Bayer Schering Pharma AG
Canonical SMILES
C1(=O)O[C@](c2cc(c(cc2)OC)OCCC)(CN1)C
CAS Number
CAS 189940-24-7
Target and Pathway
Target(s) Type IV phosphodiesterase Target Info Inhibitor [532832]
CAMP-specific 3',5'-cyclic phosphodiesterase 4B Target Info Inhibitor [532832]
CAMP-specific 3',5'-cyclic phosphodiesterase 4A Target Info Inhibitor [532832]
KEGG Pathway Purine metabolism
cAMP signaling pathway
Morphine addictionhsa00230:Purine metabolism
Morphine addiction
NetPath Pathway IL5 Signaling Pathway
IL2 Signaling Pathway
PathWhiz Pathway Purine Metabolism
Reactome DARPP-32 events
G alpha (s) signalling eventsR-HSA-180024:DARPP-32 events
G alpha (s) signalling events
WikiPathways G Protein Signaling Pathways
Myometrial Relaxation and Contraction Pathways
TSH signaling pathwayWP35:G Protein Signaling Pathways
Nuclear Receptors Meta-Pathway
Opioid SignallingWP35:G Protein Signaling Pathways
References
Ref 547377Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800015672)
Ref 532832Inhibition of phosphodiesterase 4 reduces ethanol intake and preference in C57BL/6J mice. Front Neurosci. 2014 May 27;8:129.

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