Drug Information

Drug General Information
Drug ID
D0HS2Z
Former ID
DIB013222
Drug Name
GPR119 agonists
Synonyms
GPR119 agonists (diabetes); GPR119 agonists (diabetes), Schering-Plough
Indication Diabetes [ICD9: 253.5, 588.1; ICD10:E23.2, N25.1] Investigative [552050]
Company
Schering-Plough Research Institute
Canonical SMILES
O=S(=O)(C1CC1)N1[C@H]2CC[C@@H]1C[C@@H](Oc1c(c(Nc3c(cc(c<br />c3)C#N)Cl)ncn1)C)C2
Target and Pathway
Target(s) Glucose-dependent insulinotropic receptor Target Info Agonist [543393]
KEGG Pathway cAMP signaling pathway
Insulin secretion
WikiPathways Incretin Synthesis, Secretion, and Inactivation
References
Ref 552050GPR119 agonists: a promising new approach for the treatment of type 2 diabetes and related metabolic disorders. Curr Opin Drug Discov Devel. 2009 Jul;12(4):519-32.
Ref 543393(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 126).

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