Drug Information

Drug General Information
Drug ID
D0HH8I
Former ID
DNC004713
Drug Name
FISETIN
Drug Type
Small molecular drug
Indication Discovery agent Investigative [468244]
Formula
C15H10O6
InChI
InChI=1S/C15H10O6/c16-8-2-3-9-12(6-8)21-15(14(20)13(9)19)7-1-4-10(17)11(18)5-7/h1-6,16-18,20H
InChIKey
XHEFDIBZLJXQHF-UHFFFAOYSA-N
PubChem Compound ID
5281614
PubChem Substance ID
12227, 476876, 507096, 598776, 854619, 877431, 3133267, 7584531, 7887589, 8137407, 8616674, 10318997, 11108248, 11113262, 11113263, 11341731, 11361914, 11364090, 11366652, 11369214, 11372551, 11374538, 11377376, 11408257, 11446655, 11484855, 11487316, 11488976, 11491351, 11492884, 11495010, 11537677, 12015309, 14922300, 22389243, 26612353, 26680015, 26697264, 26749675, 26753766, 29204137, 39290396, 46393572, 47960466, 48035861, 48421823, 49833373, 49970085, 50123013, 52761154
Target and Pathway
Target(s) Enoyl-ACP reductase Target Info Inhibitor [528213]
3-oxoacyl-[acyl-carrier protein] reductase Target Info Inhibitor [528213]
Cell division protein kinase 6 Target Info Inhibitor [527422]
Fatty acid synthase Target Info Inhibitor [528213]
Beta-hydroxyacyl-acp dehydratase Target Info Inhibitor [528213]
BioCyc Pathway Fatty acid biosynthesis initiation
Fatty acid elongation -- saturated
Palmitate biosynthesis
KEGG Pathway Cell cycle
p53 signaling pathway
PI3K-Akt signaling pathway
Hepatitis B
Measles
Pathways in cancer
Viral carcinogenesis
MicroRNAs in cancer
Pancreatic cancer
Glioma
Melanoma
Chronic myeloid leukemia
Small cell lung cancer
Non-small cell lung cancerhsa00061:Fatty acid biosynthesis
Metabolic pathways
Fatty acid metabolism
AMPK signaling pathway
Insulin signaling pathwaypfa00061:Fatty acid biosynthesis
Biotin metabolism
Metabolic pathways
Fatty acid metabolism
NetPath Pathway TGF_beta_Receptor Signaling Pathway
Pathway Interaction Database p73 transcription factor network
Coregulation of Androgen receptor activity
C-MYB transcription factor network
IL2 signaling events mediated by STAT5
Regulation of retinoblastoma proteinp73pathway:p73 transcription factor network
Validated transcriptional targets of deltaNp63 isoforms
PathWhiz Pathway Fatty Acid Biosynthesis
Reactome Oxidative Stress Induced Senescence
Senescence-Associated Secretory Phenotype (SASP)
Oncogene Induced Senescence
Cyclin D associated events in G1R-HSA-163765:ChREBP activates metabolic gene expression
Activation of gene expression by SREBF (SREBP)
Fatty Acyl-CoA Biosynthesis
WikiPathways DNA Damage Response
G1 to S cell cycle control
Wnt Signaling Pathway Netpath
Retinoblastoma (RB) in Cancer
Signaling Pathways in Glioblastoma
Metastatic brain tumor
miR-targeted genes in muscle cell - TarBase
miR-targeted genes in lymphocytes - TarBase
miR-targeted genes in leukocytes - TarBase
miR-targeted genes in epithelium - TarBase
Mitotic G1-G1/S phases
Cell Cycle
miRNAs involved in DNA damage response
miRNA Regulation of DNA Damage ResponseWP357:Fatty Acid Biosynthesis
Nuclear Receptors Meta-Pathway
Liver X Receptor Pathway
Activation of Gene Expression by SREBP (SREBF)
SREBF and miR33 in cholesterol and lipid homeostasis
SREBP signalling
Metabolism of water-soluble vitamins and cofactors
Integration of energy metabolism
Fatty acid, triacylglycerol, and ketone body metabolism
AMPK Signaling
References
Ref 468244(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5182).
Ref 527422J Med Chem. 2005 Feb 10;48(3):737-43.Crystal structure of a human cyclin-dependent kinase 6 complex with a flavonol inhibitor, fisetin.
Ref 528213J Med Chem. 2006 Jun 1;49(11):3345-53.Inhibition of Plasmodium falciparum fatty acid biosynthesis: evaluation of FabG, FabZ, and FabI as drug targets for flavonoids.

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