Drug Information

Drug General Information
Drug ID
D0H9QC
Former ID
DCL001236
Drug Name
S-474474
Indication Metabolic syndrome x [ICD9: 277.7; ICD10:E88.81] Phase 3 [551683]
Company
Shionogi
Target and Pathway
Target(s) Type-1 angiotensin II receptor Target Info Blocker [551683]
KEGG Pathway Calcium signaling pathway
cGMP-PKG signaling pathway
Neuroactive ligand-receptor interaction
Adrenergic signaling in cardiomyocytes
Vascular smooth muscle contraction
Renin-angiotensin system
Renin secretion
Pathways in cancer
NetPath Pathway TGF_beta_Receptor Signaling Pathway
PANTHER Pathway Angiotensin II-stimulated signaling through G proteins and beta-arrestin
Pathway Interaction Database Arf6 trafficking events
Arf6 signaling events
Angiopoietin receptor Tie2-mediated signaling
PathWhiz Pathway Angiotensin Metabolism
Muscle/Heart Contraction
Reactome Peptide ligand-binding receptors
G alpha (q) signalling events
WikiPathways ACE Inhibitor Pathway
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Peptide GPCRs
Allograft Rejection
GPCR ligand binding
GPCR downstream signaling
References
Ref 551683Clinical pipeline report, company report or official report of Shionogi (2011).
Ref 551683Clinical pipeline report, company report or official report of Shionogi (2011).

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