Drug Information

Drug General Information
Drug ID
D0H9GQ
Former ID
DCL000780
Drug Name
DOV-216303
Drug Type
Small molecular drug
Indication Severe mood disorders [ICD9: 296; ICD10:F30-F39] Discontinued in Phase 2 [536580]
Company
DOV
Formula
C11H11Cl2N
Canonical SMILES
C1C2C1(CNC2)C3=CC(=C(C=C3)Cl)Cl
InChI
1S/C11H11Cl2N/c12-9-2-1-7(3-10(9)13)11-4-8(11)5-14-6-11/h1-3,8,14H,4-6H2
InChIKey
BSMNRYCSBFHEMQ-UHFFFAOYSA-N
PubChem Compound ID
9795276
PubChem Substance ID
15196133, 24105398, 44831292, 79665352, 103585439, 104100081, 127561811, 134339264, 134346265, 137008357, 141074195, 162221510, 162571881, 172913589, 223883233, 226458441, 234991925, 251970167, 252822878
Target and Pathway
Target(s) Dopamine reuptake Target Info Inhibitor [536580]
Sodium-dependent serotonin transporter Target Info Inhibitor [536580]
Sodium-dependent noradrenaline transporter Target Info Inhibitor [536580]
KEGG Pathway Serotonergic synapse
NetPath Pathway TCR Signaling Pathway
PANTHER Pathway 5HT1 type receptor mediated signaling pathway
5HT2 type receptor mediated signaling pathway
5HT3 type receptor mediated signaling pathway
5HT4 type receptor mediated signaling pathwayP00001:Adrenaline and noradrenaline biosynthesis
Reactome Na+/Cl- dependent neurotransmitter transporters
WikiPathways Monoamine Transport
SIDS Susceptibility Pathways
NRF2 pathway
Synaptic Vesicle Pathway
Serotonin Transporter ActivityWP727:Monoamine Transport
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
References
Ref 536580Novel drugs and therapeutic targets for severe mood disorders. Neuropsychopharmacology. 2008 Aug;33(9):2080-92. Epub 2008 Jan 2.
Ref 536580Novel drugs and therapeutic targets for severe mood disorders. Neuropsychopharmacology. 2008 Aug;33(9):2080-92. Epub 2008 Jan 2.

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