Drug Information

Drug General Information
Drug ID
D0H6GF
Former ID
DNC012815
Drug Name
Mibolerone
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539884]
Formula
C20H30O2
InChI
InChI=1S/C20H30O2/c1-12-10-13-11-14(21)4-5-15(13)16-6-8-19(2)17(18(12)16)7-9-20(19,3)22/h11-12,15-18,22H,4-10H2,1-3H3/t12-,15+,16-,17+,18-,19+,20+/m1/s1
InChIKey
PTQMMNYJKCSPET-OMHQDGTGSA-N
CAS Number
CAS 3704-09-4
PubChem Compound ID
251636
PubChem Substance ID
115015, 7847065, 7979985, 9397973, 12015468, 14800585, 30049824, 47206752, 50335528, 53787315, 56464695, 57400556, 71840348, 103441270, 104445776, 128966620, 134350020, 134984886, 135650607, 137173127, 163425666, 164230523, 170466095, 178100454, 179316928, 198938532, 226872260, 241076152, 252159127, 252375495
Target and Pathway
Target(s) Androgen receptor Target Info Inhibitor [525861]
KEGG Pathway Oocyte meiosis
Pathways in cancer
Prostate cancer
NetPath Pathway EGFR1 Signaling Pathway
AndrogenReceptor Signaling Pathway
FSH Signaling Pathway
Pathway Interaction Database Regulation of nuclear SMAD2/3 signaling
Coregulation of Androgen receptor activity
Regulation of Androgen receptor activity
Nongenotropic Androgen signaling
Regulation of nuclear beta catenin signaling and target gene transcription
FOXA1 transcription factor network
Notch-mediated HES/HEY network
Reactome Nuclear Receptor transcription pathway
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
WikiPathways SIDS Susceptibility Pathways
Integrated Pancreatic Cancer Pathway
Prostate Cancer
Integrated Breast Cancer Pathway
Nuclear Receptors
Androgen receptor signaling pathway
References
Ref 539884(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2859).
Ref 525861J Med Chem. 2000 Aug 24;43(17):3344-7.Design, synthesis, and pharmacological characterization of 4-[4, 4-dimethyl-3-(4-hydroxybutyl)-5-oxo-2-thioxo-1-imidazolidinyl]- 2-iodobenzonitrile as a high-affinity nonsteroidal androgen receptor ligand.

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