Drug Information

Drug General Information
Drug ID
D0H5BC
Former ID
DIB001016
Drug Name
Tosagestin
Synonyms
Org-30659; Org-30659/estradiol
Drug Type
Small molecular drug
Indication Contraception [ICD10:Z30] Phase 2 [525775]
Company
Organon BioSciences
Formula
C21H24O2
Canonical SMILES
[C@]12([C@H]([C@H]3[C@H](C(=C)C1)[C@@H]1C(=CC(=O)CC1)CC<br />3)C=C[C@]2(C#C)O)C
CAS Number
CAS 110072-15-6
PubChem Compound ID
159355
Target and Pathway
Target(s) Progesterone receptor Target Info Agonist [527744]
KEGG Pathway Oocyte meiosis
Progesterone-mediated oocyte maturation
Pathway Interaction Database Cellular roles of Anthrax toxin
Reactome Nuclear signaling by ERBB4
Nuclear Receptor transcription pathway
WikiPathways Ovarian Infertility Genes
Signaling by ERBB4
Nuclear Receptors
References
Ref 525775Excretion balance and metabolism of the progestagen Org 30659 in healthy postmenopausal women. J Steroid Biochem Mol Biol. 2000 May;73(1-2):39-48.
Ref 527744Effects of progestins on the proliferation of estrogen-dependent human breast cancer cells under growth factor-defined conditions. J Steroid Biochem Mol Biol. 1992 Jun;42(5):457-65.

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