Drug Information

Drug General Information
Drug ID
D0H4BJ
Former ID
DNC000970
Drug Name
Muscarine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [540612]
Formula
C9H20NO2+
InChI
InChI=1S/C9H20NO2/c1-7-9(11)5-8(12-7)6-10(2,3)4/h7-9,11H,5-6H2,1-4H3/q+1/t7-,8-,9+/m0/s1
InChIKey
UQOFGTXDASPNLL-XHNCKOQMSA-N
PubChem Compound ID
9308
PubChem Substance ID
9676, 7980043, 8156660, 11111401, 16472328, 29227917, 47349362, 49994743, 50111175, 57325573, 78373694, 90341763, 103173882, 103919666, 103921290, 104320164, 121368218, 124750050, 125086646, 129406434, 134222100, 134975443, 137101313, 152105966, 162222781, 178100822, 198939053, 223440417, 226458662
Target and Pathway
Target(s) Muscarinic acetylcholine receptor M5 Target Info Agonist [535437]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Cholinergic synapse
Regulation of actin cytoskeleton
PANTHER Pathway Alzheimer disease-amyloid secretase pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Reactome Muscarinic acetylcholine receptors
G alpha (q) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
Regulation of Actin Cytoskeleton
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 540612(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3996).
Ref 535437The effects of the antagonists of muscarinic acetylcholine receptor subtypes in rat brain on urinary bladder contraction. Nippon Hinyokika Gakkai Zasshi. 2002 Mar;93(3):427-34.

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