Drug Information

Drug General Information
Drug ID
D0H2KD
Former ID
DNC005887
Drug Name
(1H-indol-2-yl)(piperazin-1-yl)methanone
Drug Type
Small molecular drug
Indication Discovery agent Investigative [527934]
Formula
C13H15N3O
Canonical SMILES
C1CN(CCN1)C(=O)C2=CC3=CC=CC=C3N2
InChI
1S/C13H15N3O/c17-13(16-7-5-14-6-8-16)12-9-10-3-1-2-4-11(10)15-12/h1-4,9,14-15H,5-8H2
InChIKey
FIVCRRVYLAXYFC-UHFFFAOYSA-N
PubChem Compound ID
921599
Target and Pathway
Target(s) Histamine H4 receptor Target Info Inhibitor [527934]
Histamine H3 receptor Target Info Inhibitor [527934]
KEGG Pathway Neuroactive ligand-receptor interactionhsa04080:Neuroactive ligand-receptor interaction
Reactome Histamine receptors
G alpha (i) signalling eventsR-HSA-390650:Histamine receptors
G alpha (i) signalling events
WikiPathways GPCR ligand binding
GPCR downstream signaling
GPCRs, OtherWP727:Monoamine Transport
GPCRs, Class A Rhodopsin-like
References
Ref 527934J Med Chem. 2005 Dec 29;48(26):8289-98.Preparation and biological evaluation of indole, benzimidazole, and thienopyrrole piperazine carboxamides: potent human histamine h(4) antagonists.
Ref 527934J Med Chem. 2005 Dec 29;48(26):8289-98.Preparation and biological evaluation of indole, benzimidazole, and thienopyrrole piperazine carboxamides: potent human histamine h(4) antagonists.

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