Drug Information

Drug General Information
Drug ID
D0H0WD
Former ID
DNC011252
Drug Name
3-isobutoxy-9H-pyrido[3,4-b]indole
Drug Type
Small molecular drug
Indication Discovery agent Investigative [531188]
Formula
C15H16N2O
Canonical SMILES
CC(C)COC1=NC=C2C(=C1)C3=CC=CC=C3N2
InChI
1S/C15H16N2O/c1-10(2)9-18-15-7-12-11-5-3-4-6-13(11)17-14(12)8-16-15/h3-8,10,17H,9H2,1-2H3
InChIKey
KWHWSXISOMCUPZ-UHFFFAOYSA-N
PubChem Compound ID
10333698
Target and Pathway
Target(s) Gamma-aminobutyric-acid receptor alpha-5 subunit Target Info Inhibitor [531188]
Gamma-aminobutyric acid receptor Target Info Inhibitor [531188]
Gamma-aminobutyric acid receptor subunit gamma-2 Target Info Inhibitor [531188]
Gamma-aminobutyric acid receptor subunit alpha-1 Target Info Inhibitor [531188]
Gamma-aminobutyric-acid receptor alpha-3 subunit Target Info Inhibitor [531188]
Gamma-aminobutyric-acid receptor alpha-2 subunit Target Info Inhibitor [531188]
KEGG Pathway Neuroactive ligand-receptor interaction
Retrograde endocannabinoid signaling
GABAergic synapse
Morphine addiction
Nicotine addictionhsa04080:Neuroactive ligand-receptor interaction
Nicotine addiction
Reactome Ligand-gated ion channel transport
GABA A receptor activationR-HSA-975298:Ligand-gated ion channel transport
GABA A receptor activation
WikiPathways Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Iron uptake and transportWP2754:Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Iron uptake and transportWP706:SIDS Susceptibility Pathways
Iron uptake and transport
References
Ref 531188Bioorg Med Chem. 2010 Nov 1;18(21):7548-64. Epub 2010 Sep 29.Design, synthesis, and subtype selectivity of 3,6-disubstituted |A-carbolines at Bz/GABA(A)ergic receptors. SAR and studies directed toward agents for treatment of alcohol abuse.
Ref 531188Bioorg Med Chem. 2010 Nov 1;18(21):7548-64. Epub 2010 Sep 29.Design, synthesis, and subtype selectivity of 3,6-disubstituted |A-carbolines at Bz/GABA(A)ergic receptors. SAR and studies directed toward agents for treatment of alcohol abuse.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Tang and Dr. Zhang.