Drug Information

Drug General Information
Drug ID
D0GS7N
Former ID
DNC011714
Drug Name
L-158809
Drug Type
Small molecular drug
Indication Hypertension [ICD9: 401; ICD10:I10-I16] Terminated [544926]
Formula
C24H23N7
Canonical SMILES
CCC1=NC2=C(N1C3=CC=C(C=C3)C4=CC=CC=C4C5=NNN=N5)N=C(C=C2<br />C)C
InChI
1S/C23H21N7/c1-4-20-25-21-14(2)13-15(3)24-23(21)30(20)17-11-9-16(10-12-17)18-7-5-6-8-19(18)22-26-28-29-27-22/h5-13H,4H2,1-3H3,(H,26,27,28,29)
InChIKey
ZXLFZNWBWMYLDB-UHFFFAOYSA-N
PubChem Compound ID
183134
Target and Pathway
Target(s) Type-2 angiotensin II receptor Target Info Inhibitor [551261]
KEGG Pathway Neuroactive ligand-receptor interaction
Adrenergic signaling in cardiomyocytes
Renin-angiotensin system
Reactome Peptide ligand-binding receptors
G alpha (i) signalling events
WikiPathways ACE Inhibitor Pathway
GPCRs, Class A Rhodopsin-like
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 544926Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001562)
Ref 551261Subtituted phenylthiophene benzoylsulfonamides with potent binding affinity to angiotensin II AT1 and AT2 receptors, Bioorg. Med. Chem. Lett. 4(1):189-194 (1994).

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