TTD | Drug: D0GQ2G

Drug General Information
Drug ID	D0GQ2G
Former ID	DIB018403
Drug Name	[3H]RY80
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[467699]
Formula	C17H15N3O3
InChI	InChI=1S/C17H15N3O3/c1-4-11-6-7-13-12(8-11)16(21)19(3)9-14-15(17(22)23-5-2)18-10-20(13)14/h1,6-8,10H,5,9H2,2-3H3
InChIKey	WDTNKNNGHGOKBH-UHFFFAOYSA-N
PubChem Compound ID	5311418
Target and Pathway
Target(s)	Gamma-aminobutyric-acid receptor alpha-5 subunit	Target Info	Modulator	[534498]
KEGG Pathway	Neuroactive ligand-receptor interaction
	Retrograde endocannabinoid signaling
	GABAergic synapse
	Morphine addiction
	Nicotine addiction
Reactome	Ligand-gated ion channel transport
Reactome	GABA A receptor activation
WikiPathways	Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
WikiPathways	Iron uptake and transport
References
Ref 467699	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4364).
Ref 534498	[3H]RY 80: A high-affinity, selective ligand for gamma-aminobutyric acidA receptors containing alpha-5 subunits. J Pharmacol Exp Ther. 1997 Nov;283(2):488-93.

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Drug Information