Drug Information

Drug General Information
Drug ID
D0G8AG
Former ID
DNC006029
Drug Name
BN-82685
Drug Type
Small molecular drug
Indication Discovery agent Investigative [527791]
Formula
C12H15N3O2S
Canonical SMILES
CC1=NC2=C(S1)C(=O)C=C(C2=O)NCCN(C)C
InChI
1S/C12H15N3O2S/c1-7-14-10-11(17)8(13-4-5-15(2)3)6-9(16)12(10)18-7/h6,13H,4-5H2,1-3H3
InChIKey
MTUYOFGUEXWKLC-UHFFFAOYSA-N
PubChem Compound ID
10286059
Target and Pathway
Target(s) M-phase inducer phosphatase 3 Target Info Inhibitor [527791]
KEGG Pathway Cell cycle
Oocyte meiosis
Progesterone-mediated oocyte maturation
MicroRNAs in cancer
PANTHER Pathway p53 pathway
Pathway Interaction Database ATR signaling pathway
ATM pathway
PLK1 signaling events
PLK3 signaling events
Reactome Polo-like kinase mediated events
Cyclin B2 mediated events
Activation of ATR in response to replication stress
RHO GTPases activate PKNs
Cyclin A/B1 associated events during G2/M transition
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
WikiPathways Monoamine Transport
DNA Damage Response
ATM Signaling Pathway
Integrated Pancreatic Cancer Pathway
Mitotic G2-G2/M phases
Cell Cycle
Cell Cycle Checkpoints
miRNA Regulation of DNA Damage Response
References
Ref 527791Bioorg Med Chem Lett. 2006 Jan 1;16(1):171-5. Epub 2005 Oct 10.Synthesis and biological evaluation of novel heterocyclic quinones as inhibitors of the dual specificity protein phosphatase CDC25C.
Ref 527791Bioorg Med Chem Lett. 2006 Jan 1;16(1):171-5. Epub 2005 Oct 10.Synthesis and biological evaluation of novel heterocyclic quinones as inhibitors of the dual specificity protein phosphatase CDC25C.

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