Drug Information

Drug General Information
Drug ID
D0G6AQ
Former ID
DIB018517
Drug Name
2-(3-bromophenyl)histamine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [538705]
Formula
C11H12BrN3
InChI
InChI=1S/C11H12BrN3/c12-9-3-1-2-8(6-9)11-14-7-10(15-11)4-5-13/h1-3,6-7H,4-5,13H2,(H,14,15)
InChIKey
VSKJPAMQPJDPLL-UHFFFAOYSA-N
PubChem Compound ID
23786499
PubChem Substance ID
47359932, 48329091, 49846677, 103193164, 135649684, 216162274, 218577428, 240899531
Target and Pathway
Target(s) Histamine H1 receptor Target Info Agonist [526569]
Histamine H4 receptor Target Info Agonist [527589]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Inflammatory mediator regulation of TRP channelshsa04080:Neuroactive ligand-receptor interaction
PANTHER Pathway Histamine H1 receptor mediated signaling pathway
Reactome Histamine receptors
G alpha (q) signalling eventsR-HSA-390650:Histamine receptors
G alpha (i) signalling events
WikiPathways Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
IL-4 Signaling Pathway
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signalingWP1825:GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 538705(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1194).
Ref 526569Multiple differences in agonist and antagonist pharmacology between human and guinea pig histamine H1-receptor. J Pharmacol Exp Ther. 2003 Jun;305(3):1104-15. Epub 2003 Mar 6.
Ref 527589Evaluation of histamine H1-, H2-, and H3-receptor ligands at the human histamine H4 receptor: identification of 4-methylhistamine as the first potent and selective H4 receptor agonist. J Pharmacol Exp Ther. 2005 Sep;314(3):1310-21. Epub 2005 Jun 9.

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